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They usually have limited therapeutic use, and some of the representatives are: Written by Dr.

Tomislav Meštrović is a medical doctor (MD) with a Ph. in biomedical and health sciences, specialist in the field of clinical microbiology, and an Assistant Professor at Croatia's youngest university - University North.

Although they are undoubtedly effective to certain extent, some aspects of their psychopharmacology have to be resolved; for example, there is poor evidence of pharmacodynamics in humans, problematic efficacy evaluation in clinical studies, as well as cumbersome production of standardized extracts and lack of bioequivalence between different extracts.

In the first part of the 20th century, the pharmacotherapy of anxiety and insomnia relied on barbiturates, which were replaced with benzodiazepines as drugs of choice in the second part of the previous century.Many current over-the-counter and prescription sleep aids have wide-reaching sedative effects and sometimes cause confusion, next-day drowsiness, worsening of sleep apnea symptoms, and an increase in the risk of falls.Orexins work on a targeted chemical system—one that is mainly involved in arousal.In modern medicine they have been largely replaced by the benzodiazepines, primarily because they can induce tolerance, physical dependence and serious withdrawal symptoms.Nevertheless, certain barbiturates are still employed as anticonvulsants (phenobarbital) and to induce anesthesia (thiopental).

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Antidepressants are sometimes prescribed for sleep difficulties because, through altering chemicals such as serotonin and norepinephrine, they can have a sedating effect.

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