Nonsedating

For information about the SORT evidence rating system, see page 453 or https://org/The literature on the common cold is extensive, but it is inconsistent in its rigor.Among the numerous studies, the clinical definition often is unclear or variable, natural and experimental colds are evaluated, and age ranges are sometimes broad and variable.Once-daily fexofenadine appears to offer effective and well-tolerated relief from the symptoms of this illness.

Among available complementary treatments, vitamin C prophylaxis may decrease the severity and duration of cold symptoms; however, vitamin C, zinc, and Echinacea are not recommended for active treatment.These symptoms resolve within a few days and are followed by nasal congestion, rhinorrhea, and cough within 24 to 48 hours after onset of the first symptoms.The second set of symptoms are what prompt most patients to see a physician for relief.1 Symptoms usually peak around day 3 or 4 and begin to resolve by day 7.12 Nasal discharge, appearing at the peak of illness, can become thick and purulent and may be misdiagnosed as a bacterial sinus infection.13Because there are no effective antivirals to cure the common cold and few effective measures to prevent it, treatment should focus on symptom relief.Complementary and alternative therapies (i.e., Echinacea, vitamin C, and zinc) are not recommended for treating common cold symptoms; however, humidified air and fluid intake may be useful without adverse side effects.Vitamin C prophylaxis may modestly reduce the duration and severity of the common cold in the general population and may reduce the incidence of the illness in persons exposed to physical and environmental stresses.

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